The ongoing transformations in society and the labor market are increasingly rapid and have a strong impact on the lives of individuals and our territories. This gives rise to new needs and demands for new knowledge and skills in many areas of expertise, which find significant and prompt responses within the network of the European Regional Labour Market Observatories (ENRLMM). This network provides high-value applied studies and research involving academics and operators from the regional observatories of many European nations. ENRLMM certainly represents a network of specialized and multidisciplinary expertise; essential elements for addressing current and future cultural challenges.