As of 2025, anticipating future developments in regional labour markets and economies remains a highly relevant topic for regional and local labour market observatories. However, the framework conditions that shape the evolution of regional labour markets and economic areas have changed significantly over the past two decades. Multiple, overlapping crises have led to fundamental transformations. As a result, local prosperity and economic capacity are shifting, social divides are deepening, and available resources are becoming increasingly scarce. In light of this growing uncertainty and volatility, the need for orientation is more pressing than ever. Data and information can provide evidence to support decision-making and action – this includes orientation toward future developments. However, forecasts of regional labour markets and economies, which often rely on linear projections of past trends, are proving to be increasingly inadequate. Alternative approaches are needed to detect new patterns that deviate from historical path dependencies.